Since 2021, aggregated from related topics
Sphingosine-1-phosphate receptor 1 (S1P1) is a cell-surface receptor that plays a key role in regulating various physiological processes, such as immune cell trafficking, vascular development, and neuroinflammation. Activation of S1P1 by its ligand, sphingosine-1-phosphate (S1P), triggers a signaling cascade that influences cell migration, proliferation, and survival. Dysregulation of S1P1 signaling has been implicated in various diseases, including cancer, autoimmune disorders, and cardiovascular diseases. Therefore, understanding the mechanisms of S1P1 activation and its downstream effects is crucial for developing therapeutic strategies targeting this receptor.